In Anno 2205 the player is the CEO of a big corporation that wants to win the Race to Space and become the biggest corporation on Earth.
The factions from 2070 have been absorbed 135 years later by a world governing body called the Global Union. The Union gives away Space Licences to settle the Moon, an undertaking reserved for huge corporations like the Big Five. But Sam Beaumont, the global secretary for interplanetary licensing, is counting on the player to win the race.
A hostile organization calling itself the Orbital Watch is taking over the former governmental lunar protectorates, which makes the situation for newcomers (like the player) even more dangerous. The global conflict escalates toward a world economy crisis that cannot be settled by the powers that be. It is the player's underdog corporation that will eventually become the hero of the day.